Cincinnati at Cleveland 6:40 PM ET
Terry Francona makes his managerial return to Progressive Field in Cleveland on Monday night when his Cincinnati Reds open a three-game series with the Guardians in the battle for the Ohio Cup.
Miami at Pittsburgh 6:40 PM ET
The Miami Marlins are expecting right-hander Eury Perez to make his long-awaited return from Tommy John surgery on Monday night when they open a three-game series against the host Pittsburgh Pirates.
Chi. Cubs at Philadelphia 6:45 PM ET
The Chicago Cubs are coming off a disappointing weekend, but they won't be getting any sympathy cards from the Philadelphia Phillies.
Tampa Bay at Boston 7:10 PM ET
Perhaps a winning weekend in the Bronx can spark the Boston Red Sox, who have had to overcome close losses and numerous injuries for a challenging start to the season that has them in fourth place in the American League East.
Atlanta at Milwaukee 7:40 PM ET
The Milwaukee Brewers will be looking to rediscover their offense when they host the struggling Atlanta Braves on Monday in the opener of a three-game series.
Toronto at St. Louis 7:45 PM ET
The Toronto Blue Jays present the stiffest possible challenge for St. Louis Cardinals starting pitcher Andre Pallante.
Athletics at LA Angels 9:38 PM ET
A pair of American League West teams coming off series victories will meet on Monday in the first of a three-game set when the Los Angeles Angels host the visiting Athletics in Anaheim, Calif.
LA Dodgers at San Diego 9:40 PM ET
The calendar says it's early June, but Padres third baseman Manny Machado swears time disappeared during San Diego's road trip.
Seattle at Arizona 9:40 PM ET
The Arizona Diamondbacks and Seattle Mariners look to regain their footing when they meet in the opener of a three-game series in Phoenix on Monday.